Juniper Publishers- Journal of Intellectual and Developmental Disabilities

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITIES Abstract The advent of nuclear neuroimaging techniques has vastly changed neurobiology and neuroscience from a bench-research oriented practice to a clinical sub discipline with diagnostic and therapeutic implications. In particular, magnetic resonance spectroscopy (MR spectroscopy) began as a tool in understanding cellular metabolism in tissues of the prostate gland, kidney, and brain, and has since evolved into a useful diagnostic and prognostic tool in clinical neurology [ 1 ]. In this review, the use of proton MR spectroscopy in the diagnosis and grading of glioma is summarized. Keywords: Glioma; Magnetic resonance spectroscopy; Neuroimaging; Metabolism Abbreviations: MRS: Magnetic Resonance Spectroscopy; NMR: Nuclear Magnetic Resonance; PMRS/HMRS: Proton Magnetic Resonance Spectroscopy. ...

  JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITIES Abstract We present experience of ketogenic diet (KD) applying in the treatment of pharmacoresistant epilepsy in a patients with glucose transporter deficiency syndrome type I (GLUT1). We observed six children with refractory epilepsy due to GLUT1. The high effectiveness of KD in the treatment of GLUT1 was demonstrated. All patients were achieved complete absence of seizures and EEG abnormalities from the beginning of KD. We noticed positive shift in cognitive and speech development for all children. Antiepileptic drugs were stopped taking due to the stable remission. There was a further positive dynamics in intelligence, psycho-emotional sphere; the children began to go a nursery school and a special school. Thus, the ketogenic diet is high effectiveness and, perhaps, the only method for GLUT1 treatment. Keywords: Ketogenic diet; Pharmacoresistant epilepsy; Intrac...