Role of Brain-derived Neurotrophic Factor in the Pathophysiology of Depression|Juniper Publishers | Global Journal of Intellectual & Developmental Disabilities

Role of Brain-derived Neurotrophic Factor in the Pathophysiology of Depression



Authored by Tridip Chatterjee

Brain-derived neurotrophic factor (BDNF) is a crucial growth factor in the central nervous system (CNS) as it is required for the development of this system as well as synaptic plasticity of the brain that underlie the learning and memory process . Furthermore, this neurotrophic factor is also implicated in mood regulation. Thus the deficiency of BDNF signaling in the brain may give rise to cognitive dysfunction and anhedonia, the important features of depression. Monoamine neurotransmission deficiencies form an important basis for the pathogenesis and maintaining the characteristic features of depression. However, in addition to monoamine neurotransmission deficiencies, BDNF deficiencies have also been noticed in depression patients. Furthermore, anti-depression treatment mediates the depression reducing effects by increasing BDNF output in brain. Thus BDNF deficiencies in brain may be an important contributor in the pathogenesis of depression.

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